Brain-derived neurotrophic factor signalling mediates antidepressant effects of lamotrigine
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منابع مشابه
Brain-derived neurotrophic factor signalling mediates antidepressant effects of lamotrigine.
The anticonvulsant drug lamotrigine has been shown to produce antidepressant effects in patients with bipolar disorder. To date, only a few preclinical studies have been conducted using lamotrigine treatment in the forced swim test (FST), an animal model of depression with low face validity. The underlying mechanisms by which lamotrigine works have not been well characterized either. This study...
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The anticonvulsant drug lamotrigine has been shown to produce strong antidepressant effects in the treatment of patients with bipolar disorder. However, to date there are few preclinical reports on its behavioral actions in animal models of depression or its underlying molecular mechanisms. The current study investigated the effects of lamotrigine in the forced swimming test and the learned hel...
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Previous studies demonstrated that antidepressant treatment increases the expression of brain-derived neurotrophic factor (BDNF) in rat hippocampus. The present study was conducted to test the hypothesis that BDNF in the hippocampus produces an antidepressant effect in behavioral models of depression, the learned helplessness (LH) and forced swim test (FST) paradigms. A single bilateral infusio...
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ژورنال
عنوان ژورنال: The International Journal of Neuropsychopharmacology
سال: 2010
ISSN: 1461-1457,1469-5111
DOI: 10.1017/s1461145710001082